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The first report of oral administration of recombinant methioninase (o-rMETase) for melanoma patient-derived orthotopic xenograft (PDOX). (a) Comparison of treatment efficacy on oral administration of recombinant methioninase (o-rMETase) and intraperitoneal injection (i.p.-rMETase) for BRAF mutant melanoma PDOX. (b) Plasma methionine level treated after recombinant methioninase (rMETase). ** p < 0.01, * p < 0.05, error bars show the SD [47].
