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Combination therapy oral administration of recombinant methioninase (o-rMETase) and S. typhimurium A1-R. (a) Fluorescence imaging of S. typhimurium A1-R-GFP cultured from the melanoma patient-derived orthotopic xenograft (PDOX). (b) Comparison of treatment. ** p < 0.01, error bars show the SD. Obtained permission from [49].
