Table 1.

Potential targets for effective Hippo pathway regulation.

Name	Mode of Action	Tested Application	Reference
Verteporfin	Disruption of YAP/TAZ- TEAD complex	HSCs isolated from C57BL/6J mice or Smo flox/flox mice IPF lung epithelial cells UUO-induced renal fibrosis CCl4-induced liver fibrosis mouse model	[49,63,68]
Melatonin	Inhibiting of the expression and activation of YAP1 via binding to MT1&MT2 melatonin receptors	Bleomycin induced experimental lung fibrosis in mice	[158]
Morin	Increased expression of MST1 and Lats1 Decreased expression of YAP/TAZ	Diethylnitrosamine (Den)-induced liver fibrosis rat model Hepatic stellate cells derived form human	[159]
ω-3 PUFA	YAP/TAZ degradation in a proteasome-dependent manner	CCl4-induced liver fibrosis mouse model Hepatic stellate cells derived from human and rat	[160]
Fasudil	Inhibitory effect on Rho/ROCK signaling	Bleomycin-induced mouse lung fibrosis	[161]
Dobutamine	Induced the cytoplasmic translocation of YAP	U2OS cell line	[162]
Statin	YAP/TAZ nuclear localization and activity	Breast cancer cell lines	[163]
Lovastatin	YAP/TAZ nuclear localization and activity	CCl4-induced liver fibrosis mouse model Human aortic vascular smooth muscle cells Human kidney cells	[79]
JQ-1	Inhibitor of bromodomain-containing protein 4 (BRD4) mediated profibrotic transcription	CCl4-induced liver fibrosis mouse model Hepatic stellate cells derived from mouse	[164]