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. 2019 Apr 28;11(5):596. doi: 10.3390/cancers11050596

Figure 3.

Figure 3

Receiver operating characteristic (ROC) curves for a combination of CA125, OPN, MIF and anti-IL-8 autoantibody biomarkers. (A) Early stage cases of discovery set. (B) Late stage cases of discovery set. (C) Early stage cases of validation set. (D) Late stage cases of validation set. A combination of CA125, OPN, MIF and IL-8 AAb levels had a significantly greater AUC (0.985) than did CA125 alone in early stage cases of discovery set (AUC = 0.885, p < 0.001). Compare to CA125 alone (AUC = 0.947), the combination also made a significant difference (AUC = 0.974, p = 0.015) in early stage cases of validation set.