Figure 3.

In vivo study with woodchuck hepatitis virus (WHV) infected woodchucks. (A) Graph plot of mean sorafenib concentration-time data for the low (2.5 mg/kg) and high (5 mg/kg) dose groups with a 5-days-on and 2-days-off schedule. (B) percent of non-tumor bearing animals after sorafenib treatment with different doses of sorafenib (n = 5), ns; not significant. (C) initial tumor volumes when tumor was detected for the first time, ** p < 0.001 by Student’s t-test, ns; not significant. (D) percent of less than 2 cm sized tumor bearing animals after the first tumor detection (n = 5), * p < 0.05 by Log-rank (Mantel-Cox) test. E, percent of necrotic change in tumor after tumor reached over 2 cm. (F) percent of less than 2 cm sized tumor bearing animals after a short-term (90 days) usage of 2.5mg/kg or 5.0 mg/kg sorafenib (n = 3), ns; not significant.