Table 3.
Effect of CB receptor or PPAR antagonist in LPS-activated FAAH knockdown cells.
| Treatment | COX-2 | IL-1β | MCP1 |
|---|---|---|---|
| siNC | 1.00 ± 0.22 | 1.00 ± 0.25 | 1.00 ± 0.18 |
| siFAAH | 0.44 ± 0.12 1 | 0.25 ± 0.11 1 | 0.28 ± 0.10 1 |
| siFAAH+SR1 | 0.37 ± 0.11 | 0.15 ± 0.06 | 0.32 ± 0.04 |
| siFAAH+SR2 | 0.33 ± 0.04 | 0.15 ± 0.05 | 0.26 ± 0.05 |
| siFAAH+GW6471 | 0.30 ± 0.05 | 0.13 ± 0.04 | 0.32 ± 0.04 |
| siFAAH+GW9662 | 0.38 ± 0.09 | 0.16 ± 0.05 | 0.34 ± 0.08 |
| siFAAH+O1918 | 0.42 ± 0.12 | 0.20 ± 0.07 | 0.37 ± 0.05 |
1 All genes expression was significantly reduced by knockdown (p < 0.01).