. 2018 Nov 16;19(18):1383–1394. doi: 10.2217/pgs-2018-0081

Table 2. . Equivocal evidence for <span class=‘highlight’>pol</span>ygenic risk scores based on nicotine metabolite ratio genome wide association study predicting smoking quantity assessed by cigarettes per day^†.

Genetic predictor	UW-TTURC (n = 1031)			COGEND (n = 1866)			ARIC (n = 5027)			MESA (n = 1158)

β	95% CI	p-value	β	95% CI	p-value	β	95% CI	p-value	β	95% CI	p-value
Loukola PRS	0.032	-0.0086–0.072	0.12	0.019	-0.024–0.063	0.39	0.035	0.011–0.060	0.0051	0.014	-0.038–0.067	0.59

Baurley PRS	0.039	-0.0035–0.082	0.07	0.035	-0.011–0.080	0.14	0.021	-0.0023–0.043	0.077	-0.00058	-0.049–0.048	0.98

^†Cigarettes per day (CPD), defined as a 4-level ordered trait (CPD ≤10; 11 ≤CPD ≤20; 21 ≤CPD ≤30; CPD ≥31, coded as 0, 1, 2, 3, respectively). Linear regression models on 4-level CPD, adjusted for age, sex, and two principal components. PRS coded as quartiles.

ARIC: Atherosclerosis Risk in Communities; COGEND: Collaborative Genetic Study of Nicotine Dependence; MESA: Multi-Ethnic Study of Atherosclerosis; PRS: Polygenic risk score; UW-TTURC: University of Wisconsin Transdisciplinary Tobacco Use Research Center.

Table 2. . Equivocal evidence for <span class=‘highlight’>pol</span>ygenic risk scores based on nicotine metabolite ratio genome wide association study predicting smoking quantity assessed by cigarettes per day†.

Table 2. . Equivocal evidence for <span class=‘highlight’>pol</span>ygenic risk scores based on nicotine metabolite ratio genome wide association study predicting smoking quantity assessed by cigarettes per day^†.