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. 2019 May 3;11(5):621. doi: 10.3390/cancers11050621

Figure 1.

Figure 1

Homeobox genes participate in the generation of hepatocellular carcinoma (HCC). The Homeobox genes positively and negatively regulate in tumorigenesis of HCC, including tumor-initiating stem-like cells, epithelial to mesenchymal transition, immunotolerance, and viral infection (hepatitis B virus (HBV) and hepatitis C virus (HCV)). The altered transcriptional regulation of Homeobox genes that we assigned in the figure dramatically rearranges the downstream genes’ expression, which participates in promotion of HCC tumorigenesis.