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. 2019 May 1;8(5):405. doi: 10.3390/cells8050405

Figure 1.

Figure 1

Effects of sodium dichloroacetate (DCA) on hypoglycemia-induced pyruvate dehydrogenase kinase 2 (PDK2) activation and pyruvate dehydrogenase (PDH) reduction. Fluorescent images show the effect of DCA treatment on PDK2 level after hypoglycemia. (A) Difference in PDK2 intensity between vehicle- and DCA-treated groups in the vulnerable CA1 after hypoglycemia. Scale bar = 10μm. (B) Difference in PDH intensity between vehicle- and DCA-treated groups in the vulnerable CA1 after hypoglycemia. In normal state, neuronal cells maintain an adequate amount of active PDH, while hypoglycemia causes a significant reduction of active PDH. However, DCA administration recovers PDH activity. Scale bar = 10μm. Bar graph shows quantification of (C) PDK2 or (D) PDH intensity in CA1 region. Data are mean ± S.E.M., n = 3 from each group. * Significantly different from vehicle treated group, p < 0.05.