Figure 3.

Administration of DCA decreases oxidative injury after hypoglycemia. Neuronal oxidative injury was determined by 4-hydroxy-2-nonenal (4HNE) (red color) staining in the hippocampal regions seven days after hypoglycemia. (A) Sham-operated groups rarely displayed the 4HNE signal in the hippocampus. DCA decreased the intensity of 4HNE fluorescence in the hippocampus compared with the saline-treated group after hypoglycemia. Scale bar = 100 μm. (B) 4HNE fluorescence intensity in the hippocampus. The fluorescence intensity indicates a significant gap between saline- and DCA-treated groups. Data are mean ± S.E.M., n = 5 for each sham group. n = 8 for each hypoglycemia group. * Significantly different from vehicle treated group, p < 0.05.