Table 1.
Tumor-associated macrophage infiltration as a predictor of patient outcomes in colorectal cancer.
| Tumor Stage | Cohort | Marker | Prognostic Value | Reference |
|---|---|---|---|---|
| Colorectal cancer (stage II–III) | 131 | CD68/VEGF | Positively correlated with OS (p = 0.01) | Khorana et al. (2003) [44] |
| Colorectal cancer (ND) | 60 | CD68 | Positively correlated with OS (p < 0.01) | Tan et al. (2005) [45] |
| Colorectal cancer (stage II–III) | 310 | CD68 | None | Bacman et al. (2007) [46] |
| Colorectal cancer (ND) | 446 | CD68 | Positively correlated with CSS (p = 0.007) | Forssell et al. (2007) [13] |
| Colorectal cancer (stage III) | 98 | CD68 | Positively correlated with OS (p = 0.041) | Zhou et al. (2010) [47] |
| Colorectal cancer (ND) | 485 | NOS2 (M1-like) | Positively correlated with CSS (p = 0.0003) | Edin et al. (2012) [14] |
| CD163 (M2-like) | Positively correlated with CSS (p < 0.0001) | |||
| Colorectal cancer (stage II–III–IV) | 159 | CD68 | Positively correlated with DSS (p = 0.02 univariate analysis) | Algars et al. (2012) [48] |
| CLEVER-1/stabilin-1 § | Positively correlated with DSS (p = 0.04 univariate analysis) | |||
| Colorectal cancer (stage III) | 208 | CD68 | Positively correlated with DFS (p = 0.005) ç | Malesci et al. (2017) [10] |
| Colorectal cancer liver metastases (CLM) | 158 | CD68 | Positively correlated with DFS (p = 0.023) | Cavnar et al. (2018) [49] |
| Colorectal cancer (stage I–II–III–IV) | 419 | CD68 | Positively correlated with OS (p = 0.003) | Li et al. (2018) [50] |
OS, overall survival; CSS, cancer-specific survival; DSS, disease-specific survival; DFS, disease-free survival; ND, not defined; § CLEVER-1/stabilin-1 was used as a marker of regulatory/suppressive macrophages; ç positive correlation occurred only in patients treated with Fluorouracil (5-FU) adjuvant therapy.