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. 2019 May 14;11(5):667. doi: 10.3390/cancers11050667

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Polycythemia and elevated erythropoietin (EPO) in Epas1^A529V mutant mice. (A) Red palm (arrow) in three-month-old mutant mice. (B) Complete blood count (CBC) test confirmed polycythemia in two-month-old mutant mice. MUT, Epas1^A529V mutant mice. WT, littermate control mice. n(WT) = 4, n(MUT) = 3; ns, p > 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. (C) Elevated plasma EPO in Epas1^A529V mutant mice. ** p < 0.01. (D) Epo expression in different tissues of four-month-old mice; n = 3 for each group. (E) EPO immunohistochemistry (IHC) staining of control and mutant kidney. Arrows indicate EPO-positive cells. RBC: red blood cells, MCV: mean corpuscular volume, WBC: white blood cells. Scale bars: top, 100 µm, bottom, 30 µm.