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. 2019 Apr 26;8(5):382. doi: 10.3390/cells8050382

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The frequency of alteration of RAC1 gene in melanomas: The oncoprint presents data obtained from c-BioPortal (February 2019) representing a combined study of 1315 samples (http://www.cbioportal.org), querying 1273 patients/1315 samples in 12 studies, as shown in the different color codes of the oncoprint (upper panel) under “Study of origin” in the figure. The percentage (5%*) represents the alteration of the RAC1 gene in patients with melanomas. The lower panel of the oncoprint represents the types of alterations of RAC1 gene in samples as shown under “Genetic Alteration” in the figure. Unaltered cases (RAC1 gene) were not included in the oncoprint. The bar diagram (figure on the right panel) represents the frequency of alterations in RAC1 gene in a few individual melanoma studies where alterations were identified. The Y-axis of the bar diagram represents the alteration frequency of the RAC1 gene (colors represent the types of alterations as shown in the figure). The frequencies of the alterations are sorted on the X-axis according to “Cancer Study”. MSS Mixed Solid Tumors (Van Allen, 2018) is not represented in the bar-diagram.