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. 2019 May 15;10(5):372. doi: 10.3390/genes10050372

Figure 1.

Figure 1

High-mobility group A protein 1 (HMGA1) mRNA and protein expression pattern in endometrioid endometrial adenocarcinomas (EEC). HMGA1 gene and protein expression analysis of the endometrioid endometrial adenocarcinoma (EEC) patients analyzed in this study, according to clinicopathological characteristics, by real-time quantitative PCR (RT-qPCR) and immunohistochemistry (IHC), respectively. (A) Tumor staging: HMGA1 mRNA expression performed in 10 EEC samples from stage IA, 10 from stage IB, 10 from stage II, 10 from stage III, six samples from stage IV and in six normal endometrial samples. (B) Histological grade: HMGA1 mRNA expression performed in 11 well differentiated (G1), 22 moderately differentiated (G2), 13 poorly differentiated (G3) EEC samples and in six normal endometrial samples. (C) Tumor size: Correlation between HMGA1 mRNA levels and tumor size. Evaluation of HMGA1 protein expression was performed in six normal endometrial tissue samples (D), five EEC samples from stage IA (E), five from stage IB (F), five from stage II (G), five from stage III (H) and five samples from stage IV (I) chosen randomly out of the 46 patients analyzed for gene expression. Magnification of photomicrographs: 100×. (J) Correlation between HMGA1 mRNA and protein expression. Statistical analyses were performed based on a confidence interval of 95%. Data with p < 0.05 were considered statistically significant. * = p < 0.05; ** = p < 0.005; *** = p < 0.0005.