Table 5.

5-year rate of distant metastases of 598 patients.

Univariate Analysis					Multivariate Analysis
Patient and Tumour Characteristics	Number	5Y distant Metastases	95% CI	p	Hazard Ratio	95% CI	p
Total	598	16.7%	13.6–19.8
BMI WHO
BMI < 18.5 kg/m2 underweight	5	40.0%	0–82.9		1.7	0.4–7.2	0.493
BMI 18.5–25 kg/m2 normal range	209	16.2%	11.1–21.3		1.0
BMI 25–30 kg/m2 overweight	257	17.3%	12.6–22.0		1.2	0.8–2.0	0.340
BMI 30–35 kg/m2 obese class I	102	11.9%	5.6–18.2		0.9	0.5–1.7	0.813
BMI 35–40 kg/m2 obese class II	16	34.0%	9.7–58.3		1.9	0.8–4.8	0.153
BMI ≥ 40 kg/m2 obese class III	9	22.2%	0–49.4	0.225	1.4	0.3–5.8	0.678
BMI Groups
Group 1: BMI 18.5–35	568	15.9%	12.8–19.0		1.0
Group 2: BMI <18.5 or ≥35	30	31.4%	14.3–48.5	0.034	1.6	0.8–3.1	0.177
Age
≤65	315	14.1%	10.2–18.0
>65	283	19.7%	14.8–24.6	0.085
Sex
Male	394	16.3%	12.6–20.0
Female	204	17.4%	12.1–22.7	0.861
Localisation
<6 cm	202	13.8%	9.0–18.8
6–12 cm	271	17.9%	13.2–22.6
12–16 cm	125	18.8%	11.7–25.9	0.541
UICC-stage
I	150	9.8%	4.9–14.7		1.0
II	65	23.1%	12.5–33.7		2.1	1.0–4.4	0.041
III	65	30.7%	18.4–43.0		2.7	1.4–5.5	0.003
y0	55	1.9%	0–5.4		0.2	0–1.3	0.086
yI	101	6.9%	2.0–11.8		0.6	0.2–1.4	0.250
yII	74	23.3%	13.7–32.9		2.3	1.1–4.6	0.019
yIII	88	30.3%	20.5–40.1	<0.001	3.1	1.7–5.8	<0.001
Abdominoperineal excision
No	509	16.4%	13.1–19.7
Yes	89	18.0%	9.8–26.2	0.313
ASA-Score a
ASA 1&2	481	15.2%	11.9–18.5
ASA 3&4	113	24.2%	15.8–32.6	0.052
CEA-level b
Normal (<5 ng/L)	432	14.1%	10.8–17.4		1.0
Elevated(≥5 ng/L)	88	31.6%	21.6–41.6	<0.001	1.9	1.2–3.0	0.005

^a 4 Patients excluded due to unknown ASA-Score, ^b 78 Patients excluded due to unknown CEA-level.