Table 1.

List of reported ATG4B regulators.

Name/Compound ID	IC50	Methods	Effect on ATG4B	Effect on Autophagy	Effect on Cancer	Ref.
201508	2.3 µM	LC3B-PLA2 assay	Inhibiting	N.R.	N.R.	[107]
1502245	3.0 µM	LC3B-PLA2 assay	Inhibiting	N.R.	N.R.	[107]
1504078	1.7 µM	LC3B-PLA2 assay	Inhibiting	N.R.	N.R.	[107]
1504080	1.1 µM	LC3B-PLA2 assay	Inhibiting	N.R.	N.R.	[107]
Tioconazole	1.8 µM	LC3B-PLA2 assay	Inhibiting	Inhibiting	Enhancing Dox-induced cytotoxicity in colorectal cancer	[44]
Z-FA-FMK	14.8 µM	TR-FRET assay	Inhibiting	N.R.	N.R.	[100]
Z-FG-FMK	1.13 µM	TR-FRET assay	Inhibiting	N.R.	N.R.	[100]
FMK-9a	80 nM	TR-FRET assay	Inhibiting	Inducing	Having no effect on the survival of HeLa cells	[101,108]
Hypericin	30 µM	FRET assay	Inhibiting	N.R.	N.R.	[109]
Aurin	8.8 µM	FRET assay	Inhibiting	N.R.	N.R.	[109]
LV-320	24.5 µM	Fluorescent peptide substrate assay	Inhibiting	Inhibiting	N.R.	[103]
UAMC-2526	N.R.	LC3-GST cleavage assay	Inhibiting	Inhibiting	Enhancing Oxaliplatin-induced cytotoxicity in colorectal cancer	[110]
NSC185058	51 µM	In silico screening, LC3-GST cleavage assay	Inhibiting	Inhibiting	Suppressing the development ofSao-2 cells; enhancing the anti-glioblastoma activity of radiation therapy	[31,62]
S130	3.2 µM	In silico screening, FRET assay	Inhibiting	Inhibiting	Arresting the growth of colorectal cancer	[6]
Flubendazole	N.R.	In silico analysis	Inducing	Inducing	Inducing autophagic cell death in MDA-MB-231 cells	[102]

N.R.: not reported.