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. 2019 Apr 30;11(5):601. doi: 10.3390/cancers11050601

Table 4.

Candidate downstream genes modulated by TNS4 in lung adenocarcinoma.

Entrez Gene Gene Symbol Gene Name GSE19188 FC (log2) A549 si-TNS4-2 Transfectant FC (log2) TCGA OncoLnc p-Value
114904 C1QTNF6 C1q and tumor necrosis factor related protein 6 2.046 −1.159 <0.0001
983 CDK1 Cyclin-dependent kinase 1 2.400 −1.119 0.0003
10615 SPAG5 Sperm-associated antigen 5 2.196 −1.598 0.0003
84951 TNS4 Tensin 4 2.560 −2.690 0.0003
4288 MKI67 Marker of proliferation Ki-67 2.835 −1.475 0.0004
8208 CHAF1B Chromatin assembly factor 1, subunit B (p60) 1.723 −1.112 0.0005
9824 ARHGAP11A Rho GTPase activating protein 11A 1.638 −1.263 0.0007
9055 PRC1 Protein regulator of cytokinesis 1 2.540 −1.120 0.0007
171177 RHOV Ras homolog family member V 2.330 −1.890 0.0008
1033 CDKN3 Cyclin-dependent kinase inhibitor 3 2.889 −1.594 0.0011
6241 RRM2 Ribonucleotide reductase M2 3.000 −1.356 0.0013
57405 SPC25 SPC25, NDC80 kinetochore complex component 2.417 −1.456 0.0014
5318 PKP2 Plakophilin 2 1.584 −1.108 0.0016
701 BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.669 −1.278 0.0017
4085 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 2.768 −1.726 0.0018
81624 DIAPH3 Diaphanous-related formin 3 1.926 −1.016 0.0022
3832 KIF11 Kinesin family member 11 2.479 −1.007 0.0022
79019 CENPM Centromere protein M 2.391 −1.057 0.0023
55635 DEPDC1 DEP domain containing 1 3.443 −1.282 0.0024
147841 SPC24 SPC24, NDC80 kinetochore complex component 2.179 −1.490 0.0031
195828 ZNF367 Zinc finger protein 367 1.583 −1.454 0.0033
1063 CENPF Centromere protein F, 350/400kDa 2.985 −1.129 0.0048
83540 NUF2 NUF2, NDC80 kinetochore complex component 3.442 −1.069 0.0048
29089 UBE2T Ubiquitin-conjugating enzyme E2T 3.317 −1.092 0.0051
7348 UPK1B Uroplakin 1B 1.603 −1.179 0.0059
11130 ZWINT ZW10 interacting kinetochore protein 2.184 −1.188 0.0064
11169 WDHD1 WD repeat and HMG-box DNA binding protein 1 2.094 −1.151 0.0065
55215 FANCI Fanconi anemia, complementation group I 2.298 −1.563 0.0073
4176 MCM7 Minichromosome maintenance complex component 7 1.555 −1.164 0.0076
10403 NDC80 NDC80 kinetochore complex component 2.493 −1.053 0.0076
699 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 3.206 −1.180 0.0081
79075 DSCC1 DNA replication and sister chromatid cohesion 1 1.704 −1.187 0.0088
51514 DTL Denticleless E3 ubiquitin protein ligase homolog (Drosophila) 2.098 −1.187 0.0091
8914 TIMELESS Timeless circadian clock 1.650 −1.447 0.0093
79733 E2F8 E2F transcription factor 8 2.879 −2.313 0.0114
4605 MYBL2 v-Myb avian myeloblastosis viral oncogene homolog-like 2 3.003 −1.063 0.0122
5427 POLE2 Polymerase (DNA directed), epsilon 2, accessory subunit 1.600 −1.074 0.0122
10331 B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 1.608 −1.005 0.0129
7083 TK1 Thymidine kinase 1, soluble 2.086 −1.399 0.0131
6790 AURKA Aurora kinase A 2.542 −1.018 0.0132
79623 GALNT14 Polypeptide N-acetylgalactosaminyltransferase 14 2.572 −1.075 0.0140
64151 NCAPG Non-SMC condensin I complex, subunit G 2.833 −2.675 0.0147
8318 CDC45 Cell division cycle 45 3.829 −1.605 0.0159
55165 CEP55 Centrosomal protein 55kDa 2.875 −1.077 0.0203
54478 FAM64A Family with sequence similarity 64, member A 2.713 −1.697 0.0219
79172 CENPO Centromere protein O 1.620 −1.048 0.0248
2491 CENPI Centromere protein I 2.088 −1.685 0.0258
1356 CP Ceruloplasmin (ferroxidase) 1.604 −2.134 0.0300
2244 FGB Fibrinogen beta chain 1.887 −3.066 0.0305
29128 UHRF1 Ubiquitin-like with PHD and ring finger domains 1 2.576 −1.442 0.0312
1058 CENPA Centromere protein A 3.488 −1.338 0.0365
2877 GPX2 Glutathione peroxidase 2 (gastrointestinal) 3.579 −1.038 0.0446
5888 RAD51 RAD51 recombinase 2.085 −1.344 0.0478
8438 RAD54L RAD54-like (S. cerevisiae) 2.920 −1.013 0.0509
1789 DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.606 −1.029 0.0607
5984 RFC4 Replication factor C (activator 1) 4, 37kDa 2.004 −1.166 0.0938
91057 CCDC34 Coiled-coil domain containing 34 1.995 −1.985 0.1035
202915 TMEM184A Transmembrane protein 184A 1.940 −1.983 0.1067
8038 ADAM12 ADAM metallopeptidase domain 12 2.753 −1.464 0.1097
51557 LGSN Lengsin, lens protein with glutamine synthetase domain 1.721 −1.008 0.1253
4151 MB Myoglobin 1.614 −2.307 0.1346
201299 RDM1 RAD52 motif containing 1 1.503 −1.596 0.1583
5080 PAX6 Paired box 6 1.602 −1.692 0.1649
114907 FBXO32 F-box protein 32 1.990 −1.044 0.1654
286151 FBXO43 F-box protein 43 1.569 −1.906 0.1729
10293 TRAIP TRAF interacting protein 2.362 −1.114 0.1742
83990 BRIP1 BRCA1 interacting protein C-terminal helicase 1 2.051 −1.439 0.1829
349136 WDR86 WD repeat domain 86 1.653 −1.306 0.1904
1870 E2F2 E2F transcription factor 2 1.704 −1.075 0.1993
3007 HIST1H1D Histone cluster 1, H1d 1.568 −1.265 0.2918
6676 SPAG4 Sperm-associated antigen 4 1.552 −1.003 0.3275
200844 C3orf67 Chromosome 3 open reading frame 67 1.584 −1.436 0.3482
57016 AKR1B10 Aldo-keto reductase family 1, member B10 (aldose reductase) 3.628 −2.490 0.3591
1719 DHFR Dihydrofolate reductase 1.538 −1.033 0.4901
8581 LY6D Lymphocyte antigen 6 complex, locus D 2.171 −1.384 0.5123
6518 SLC2A5 Solute carrier family 2 (facilitated glucose/fructose transporter), member 5 1.986 −1.018 0.5410
10535 RNASEH2A Ribonuclease H2, subunit A 1.751 −1.020 0.5517
10018 BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.592 −1.310 0.5755
25837 RAB26 RAB26, member RAS oncogene family 2.112 −1.420 0.5804
57834 CYP4F11 Cytochrome P450, family 4, subfamily F, polypeptide 11 1.795 −1.032 0.6899
100133941 CD24 CD24 molecule 2.092 −1.777 0.7765
56521 DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.208 −1.687 0.7922
3141 HLCS Holocarboxylase synthetase 1.791 −1.020 0.8947
222962 SLC29A4 Solute carrier family 29 (equilibrative nucleoside transporter), member 4 1.617 −1.100 0.9072
1645 AKR1C1 Aldo-keto reductase family 1, member C1 2.257 –1.546 0.9583
152404 IGSF11 Immunoglobulin superfamily, member 11 1.590 –1.572 0.9790
85285 KRTAP4-1 Keratin-associated protein 4-1 2.215 –1.029 no data
25859 PART1 Prostate androgen-regulated transcript 1 (non-protein coding) 1.915 –1.383 no data