Table 4.
Candidate downstream genes modulated by TNS4 in lung adenocarcinoma.
| Entrez Gene | Gene Symbol | Gene Name | GSE19188 FC (log2) | A549 si-TNS4-2 Transfectant FC (log2) | TCGA OncoLnc p-Value |
|---|---|---|---|---|---|
| 114904 | C1QTNF6 | C1q and tumor necrosis factor related protein 6 | 2.046 | −1.159 | <0.0001 |
| 983 | CDK1 | Cyclin-dependent kinase 1 | 2.400 | −1.119 | 0.0003 |
| 10615 | SPAG5 | Sperm-associated antigen 5 | 2.196 | −1.598 | 0.0003 |
| 84951 | TNS4 | Tensin 4 | 2.560 | −2.690 | 0.0003 |
| 4288 | MKI67 | Marker of proliferation Ki-67 | 2.835 | −1.475 | 0.0004 |
| 8208 | CHAF1B | Chromatin assembly factor 1, subunit B (p60) | 1.723 | −1.112 | 0.0005 |
| 9824 | ARHGAP11A | Rho GTPase activating protein 11A | 1.638 | −1.263 | 0.0007 |
| 9055 | PRC1 | Protein regulator of cytokinesis 1 | 2.540 | −1.120 | 0.0007 |
| 171177 | RHOV | Ras homolog family member V | 2.330 | −1.890 | 0.0008 |
| 1033 | CDKN3 | Cyclin-dependent kinase inhibitor 3 | 2.889 | −1.594 | 0.0011 |
| 6241 | RRM2 | Ribonucleotide reductase M2 | 3.000 | −1.356 | 0.0013 |
| 57405 | SPC25 | SPC25, NDC80 kinetochore complex component | 2.417 | −1.456 | 0.0014 |
| 5318 | PKP2 | Plakophilin 2 | 1.584 | −1.108 | 0.0016 |
| 701 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 2.669 | −1.278 | 0.0017 |
| 4085 | MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 2.768 | −1.726 | 0.0018 |
| 81624 | DIAPH3 | Diaphanous-related formin 3 | 1.926 | −1.016 | 0.0022 |
| 3832 | KIF11 | Kinesin family member 11 | 2.479 | −1.007 | 0.0022 |
| 79019 | CENPM | Centromere protein M | 2.391 | −1.057 | 0.0023 |
| 55635 | DEPDC1 | DEP domain containing 1 | 3.443 | −1.282 | 0.0024 |
| 147841 | SPC24 | SPC24, NDC80 kinetochore complex component | 2.179 | −1.490 | 0.0031 |
| 195828 | ZNF367 | Zinc finger protein 367 | 1.583 | −1.454 | 0.0033 |
| 1063 | CENPF | Centromere protein F, 350/400kDa | 2.985 | −1.129 | 0.0048 |
| 83540 | NUF2 | NUF2, NDC80 kinetochore complex component | 3.442 | −1.069 | 0.0048 |
| 29089 | UBE2T | Ubiquitin-conjugating enzyme E2T | 3.317 | −1.092 | 0.0051 |
| 7348 | UPK1B | Uroplakin 1B | 1.603 | −1.179 | 0.0059 |
| 11130 | ZWINT | ZW10 interacting kinetochore protein | 2.184 | −1.188 | 0.0064 |
| 11169 | WDHD1 | WD repeat and HMG-box DNA binding protein 1 | 2.094 | −1.151 | 0.0065 |
| 55215 | FANCI | Fanconi anemia, complementation group I | 2.298 | −1.563 | 0.0073 |
| 4176 | MCM7 | Minichromosome maintenance complex component 7 | 1.555 | −1.164 | 0.0076 |
| 10403 | NDC80 | NDC80 kinetochore complex component | 2.493 | −1.053 | 0.0076 |
| 699 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 3.206 | −1.180 | 0.0081 |
| 79075 | DSCC1 | DNA replication and sister chromatid cohesion 1 | 1.704 | −1.187 | 0.0088 |
| 51514 | DTL | Denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 2.098 | −1.187 | 0.0091 |
| 8914 | TIMELESS | Timeless circadian clock | 1.650 | −1.447 | 0.0093 |
| 79733 | E2F8 | E2F transcription factor 8 | 2.879 | −2.313 | 0.0114 |
| 4605 | MYBL2 | v-Myb avian myeloblastosis viral oncogene homolog-like 2 | 3.003 | −1.063 | 0.0122 |
| 5427 | POLE2 | Polymerase (DNA directed), epsilon 2, accessory subunit | 1.600 | −1.074 | 0.0122 |
| 10331 | B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 1.608 | −1.005 | 0.0129 |
| 7083 | TK1 | Thymidine kinase 1, soluble | 2.086 | −1.399 | 0.0131 |
| 6790 | AURKA | Aurora kinase A | 2.542 | −1.018 | 0.0132 |
| 79623 | GALNT14 | Polypeptide N-acetylgalactosaminyltransferase 14 | 2.572 | −1.075 | 0.0140 |
| 64151 | NCAPG | Non-SMC condensin I complex, subunit G | 2.833 | −2.675 | 0.0147 |
| 8318 | CDC45 | Cell division cycle 45 | 3.829 | −1.605 | 0.0159 |
| 55165 | CEP55 | Centrosomal protein 55kDa | 2.875 | −1.077 | 0.0203 |
| 54478 | FAM64A | Family with sequence similarity 64, member A | 2.713 | −1.697 | 0.0219 |
| 79172 | CENPO | Centromere protein O | 1.620 | −1.048 | 0.0248 |
| 2491 | CENPI | Centromere protein I | 2.088 | −1.685 | 0.0258 |
| 1356 | CP | Ceruloplasmin (ferroxidase) | 1.604 | −2.134 | 0.0300 |
| 2244 | FGB | Fibrinogen beta chain | 1.887 | −3.066 | 0.0305 |
| 29128 | UHRF1 | Ubiquitin-like with PHD and ring finger domains 1 | 2.576 | −1.442 | 0.0312 |
| 1058 | CENPA | Centromere protein A | 3.488 | −1.338 | 0.0365 |
| 2877 | GPX2 | Glutathione peroxidase 2 (gastrointestinal) | 3.579 | −1.038 | 0.0446 |
| 5888 | RAD51 | RAD51 recombinase | 2.085 | −1.344 | 0.0478 |
| 8438 | RAD54L | RAD54-like (S. cerevisiae) | 2.920 | −1.013 | 0.0509 |
| 1789 | DNMT3B | DNA (cytosine-5-)-methyltransferase 3 beta | 1.606 | −1.029 | 0.0607 |
| 5984 | RFC4 | Replication factor C (activator 1) 4, 37kDa | 2.004 | −1.166 | 0.0938 |
| 91057 | CCDC34 | Coiled-coil domain containing 34 | 1.995 | −1.985 | 0.1035 |
| 202915 | TMEM184A | Transmembrane protein 184A | 1.940 | −1.983 | 0.1067 |
| 8038 | ADAM12 | ADAM metallopeptidase domain 12 | 2.753 | −1.464 | 0.1097 |
| 51557 | LGSN | Lengsin, lens protein with glutamine synthetase domain | 1.721 | −1.008 | 0.1253 |
| 4151 | MB | Myoglobin | 1.614 | −2.307 | 0.1346 |
| 201299 | RDM1 | RAD52 motif containing 1 | 1.503 | −1.596 | 0.1583 |
| 5080 | PAX6 | Paired box 6 | 1.602 | −1.692 | 0.1649 |
| 114907 | FBXO32 | F-box protein 32 | 1.990 | −1.044 | 0.1654 |
| 286151 | FBXO43 | F-box protein 43 | 1.569 | −1.906 | 0.1729 |
| 10293 | TRAIP | TRAF interacting protein | 2.362 | −1.114 | 0.1742 |
| 83990 | BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 2.051 | −1.439 | 0.1829 |
| 349136 | WDR86 | WD repeat domain 86 | 1.653 | −1.306 | 0.1904 |
| 1870 | E2F2 | E2F transcription factor 2 | 1.704 | −1.075 | 0.1993 |
| 3007 | HIST1H1D | Histone cluster 1, H1d | 1.568 | −1.265 | 0.2918 |
| 6676 | SPAG4 | Sperm-associated antigen 4 | 1.552 | −1.003 | 0.3275 |
| 200844 | C3orf67 | Chromosome 3 open reading frame 67 | 1.584 | −1.436 | 0.3482 |
| 57016 | AKR1B10 | Aldo-keto reductase family 1, member B10 (aldose reductase) | 3.628 | −2.490 | 0.3591 |
| 1719 | DHFR | Dihydrofolate reductase | 1.538 | −1.033 | 0.4901 |
| 8581 | LY6D | Lymphocyte antigen 6 complex, locus D | 2.171 | −1.384 | 0.5123 |
| 6518 | SLC2A5 | Solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 1.986 | −1.018 | 0.5410 |
| 10535 | RNASEH2A | Ribonuclease H2, subunit A | 1.751 | −1.020 | 0.5517 |
| 10018 | BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 1.592 | −1.310 | 0.5755 |
| 25837 | RAB26 | RAB26, member RAS oncogene family | 2.112 | −1.420 | 0.5804 |
| 57834 | CYP4F11 | Cytochrome P450, family 4, subfamily F, polypeptide 11 | 1.795 | −1.032 | 0.6899 |
| 100133941 | CD24 | CD24 molecule | 2.092 | −1.777 | 0.7765 |
| 56521 | DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 2.208 | −1.687 | 0.7922 |
| 3141 | HLCS | Holocarboxylase synthetase | 1.791 | −1.020 | 0.8947 |
| 222962 | SLC29A4 | Solute carrier family 29 (equilibrative nucleoside transporter), member 4 | 1.617 | −1.100 | 0.9072 |
| 1645 | AKR1C1 | Aldo-keto reductase family 1, member C1 | 2.257 | –1.546 | 0.9583 |
| 152404 | IGSF11 | Immunoglobulin superfamily, member 11 | 1.590 | –1.572 | 0.9790 |
| 85285 | KRTAP4-1 | Keratin-associated protein 4-1 | 2.215 | –1.029 | no data |
| 25859 | PART1 | Prostate androgen-regulated transcript 1 (non-protein coding) | 1.915 | –1.383 | no data |