Table 3. . Logistic regression association between prescribing behavior and genotype.
| Variable | (A) Poor/ultrarapid N = 8 (%) | (B) Reduced N = 32 (%) | (C) Normal/indeterminate N = 62 (%) | OR (95% CI) (A) v (C) | OR (95% CI) (B) v (C) | p-value |
|---|---|---|---|---|---|---|
| Alternate opioid prescribed by 30 days (Y) | 3 (38) | 3 (9) | 3 (5) | 15.1 (1.8–161.3) | 2.3 (0.4–13.7) | 0.04 |
| Alternate opioid prescribed by 60 days (Y) | 4 (50) | 4 (12) | 3 (5) | 19.0 (2.8– 160.4) | 2.9 (0.6– 16.2) | 0.01 |
| Alternate opioid prescribed by 90 days (Y) | 4 (50) | 8 (25) | 7 (11) | 9.5 (1.7– 57.3) | 2.6 (0.8– 8.8) | 0.03 |
| Alternative opioid prescribed during follow-up (Y)† | 5 (63) | 11 (34) | 17 (27) | 4.6 (0.9–25.9) | 1.5 (0.6– 4.0) | 0.16 |
| Discontinuation of tramadol or codeine during follow-up (Y)† | 7 (88) | 12 (38) | 15 (24) | 24.7 (3.6– 503.1) | 1.9 (0.7– 5.1) | 0.002 |
| Dose change (Y)† | 1 (13) | 4 (13) | 13 (21) | 0.6 (0.03– 4.6) | 0.7 (0.2– 2.2) | 0.79 |
| Refill prescribed (Y)† | 0 (0) | 14 (44) | 30 (48) | 0 (NA)‡ | 0.9 (0.3– 2.2) | 0.01 |
†All available follow-up (up to 1 year) was used to determine the outcome.
‡95% CI not available due to sample size.
OR: Odds ratio; Y: Yes or positive outcome.
All p-value calculations are based on a multivariate logistic regression model.