Table 4. . Logistic regression association between prescribing behavior and genotype adjusted for drug–drug interactions.
| Variable | (A) Poor/ultrarapid N = 25 (%) | (B) Reduced N = 30 (%) | (C) Normal/indeterminate N = 47 (%) | OR (95% CI) (A) v (C) | OR (95% CI) (B) v (C) | p-value |
|---|---|---|---|---|---|---|
| Alternate opioid prescribed by 30 days (Y) | 6 (24) | 0 (0) | 3 (6) | 4.6 (NA)† | 0 (NA)† | 0.01 |
| Alternate opioid prescribed by 60 days (Y) | 7 (28) | 1 (3) | 3 (6) | 4.9 (1.2–26.1) | 0.6 (0.03–5.0) | 0.003 |
| Alternate opioid prescribed by 90 days (Y) | 7 (28) | 6 (20) | 6 (13) | 3.4 (0.9–13.4) | 1.8 (0.4–3.3) | 0.19 |
| Alternative opioid prescribed during follow-up (Y)‡ | 13 (52) | 8 (27) | 12 (26) | 3.6 (1.3–11.20 | 1.3 (0.4–4.1) | 0.054 |
| Discontinuation of tramadol or codeine during follow-up (Y)‡ | 13 (52) | 11 (37) | 10 (21) | 5.0 (1.7–16.7) | 2.8 (0.9–0.1) | 0.01 |
| Dose change (Y)‡ | 3 (12) | 4 (13) | 11 (23) | 0.5 (0.1–1.8) | 0.7 (0.2–2.6) | 0.58 |
| Refill prescribed (Y)‡ | 6 (24) | 14 (47) | 23 (49) | 0.3 (0.1–0.9) | 1.1 (0.4–3.1) | 0.046 |
†95% CI not available due to sample size.
‡All available follow-up (up to 1 year) was used to determine the outcome.
OR: Odds ratio; Y: Yes or positive outcome.
All p-value calculations are based on a multivariate logistic regression model.