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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Schematic diagram of the mechanism of small interfering RNA (siRNA) in targeting mRNA for gene silencing (left) and exogenous siRNA duplex delivery into the cytoplasmic region via passive and active targeted delivery (right).