Table 1.
List of targeted genes for siRNA knockdown in breast cancer.
| Targeted Genes | Delivery Carrier | Cell Line | Animal Model | References |
|---|---|---|---|---|
| ER, BCL-2, ERBB2, and EGFR | Carbonate apatite | MCF-7, MDA-MB-231 | Balb/c | [82] |
| egfr1 and erbb2 | Carbonate apatite | MCF-7 | Balb/c | [114] |
| BCL-2 and BCL-XL | Calcium phosphate pEG-polyanion | MCF-7 | NA | [109] |
| MAPK | Barium salts nanoparticles | MCF-7 | Balb/c | [108] |
| VEGF | Polycation liposome-encapsulated calcium phosphate nanoparticles (PLCP) | MCF-7 | Balb/c | [110] |
| EpCAM | Polyethyleneimine | MCF-7 and WERI-Rb1 | NA | [111] |
| PLK1 | Mesoporous silica coated with PEI and PEG | Bt549 and MDA-MB-231 | SCID hairless SHO (Crl:SHO-Prkdc scid Hr hr) | [112] |
| uPA and MMP9 | Interferin transfection reagent | MDA-MB-231 | NA | [113] |
| CDK8 | Lipofectamine 2000 | MDA-MB-231 and MCF-7 | NA | [114] |
| c-ROS1 | Carbonate apatite | MCF-7 | NA | [115] |
| IKKε | Lipofectamine 2000 | SK-BR-3 and MCF-7 | NA | [116] |
| Cyclin E | Oligofectamine | SK-BR3, MDA-MB-157, MDA-MB-436, T47D, and MDA-MB-453 | Nude mice | [117] |
| HER2 | Mesoporous silica coated with cationic polymer and PEG | BT474 | NA | [118] |
NA: No information available.