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. 2019 Apr 26;10(5):323. doi: 10.3390/genes10050323

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The CFA28 locus and variants effects on TF binding. (A) UCSC Genome Browser display centered around the CFA28 GWAS locus. The locus (black bar) is in the intron of ADRB1-AU1 (green) upstream of ADRB1 (blue). Both variants are indicated within the region. Also shown are the curated annotations from ORegAnno (orange). (B) In silico prediction of transcription factor binding surround the two derived alleles in wolf with low frequency. Transcription factor prediction was performed using AliBaba2 at the significant variant plus/minus 20bp in single- (derived) and double-coated (ancestral) alleles. Binding is denoted by a black line below target sequence. (C) The consensus sequence for each of the four transcription factors identified in (B) are shown. AP-1 is composed of a dimer of FOS and JUN. The two variant positions lie within well conserved regions of each transcription factor.