Table 1.
Identified metabolites and associated pathways in BC tissue and urine samples.
| Metabolic altered Pathways | Sample | Metabolites | p | Impact |
|---|---|---|---|---|
| Alanine, aspartate, glutamate | Tissue | Alanine, glutamine, glutamate | 6.5E-4 | 0.44 |
| Urine | Alanine, glutamine, succinate | 6.5E-4 | 0.26 | |
| Taurine and hypotaurine | Tissue | Taurine, alanine | 9.0E-3 | 0.36 |
| Urine | Taurine, alanine | 9.0E-3 | 0.36 | |
| Aminoacyl-tRNA biosynthesis | Tissue | Proline, glycine, alanine, glutamine, threonine, glutamate | 1.0E-5 | 0.06 |
| Urine | Phenylalanine, glutamine, valine, alanine, lysine | 1.6E-4 | 0.56 | |
| Methane | Tissue | Glycine, methanol | 2.6E-2 | 0.02 |
| Urine | Trimethylamine N-oxide, methanol | 2.5E-2 | 0.02 | |
| Glycine, serine, threonine | Tissue | Glycine, creatine, choline, threonine | 3.5E-4 | 0.29 |
| Glutathione | Tissue | Glutathione, glycine, glutamate | 2.0E-3 | 0.25 |
| Glycerolipid | Tissue | Fatty acid, glycerol | 2.3E-2 | 0.19 |
| Arginine and proline | Tissue | Glutamine, glutamate, proline, creatine | 2.0E-3 | 0.17 |
| Glutamine and glutamate | Tissue | Glutamine, glutamate | 3.0E-3 | 0.14 |
| Glycerophospholipid | Tissue | Choline, glycerophosphocholine, phosphocholine | 3.0E-3 | 0.08 |
| Citrate cycle | Urine | Citrate, succinate | 9.0E-3 | 0.08 |
| Phenylalanine | Urine | Succinate, phenylalanine, hippuric acid | 4.0E-3 | 0.07 |
| Nitrogen metabolism | Urine | Phenylalanine, taurine, glutamine | 2.7E-3 | 0.05 |
| Propanoate | Urine | Succinate, lactic acid, valine | 2.0E-3 | 0.05 |