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. 2019 May 9;11(5):642. doi: 10.3390/cancers11050642

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combined antitumor effects of cannabidiol and TRAIL on colorectal cancer in vivo (A,B) DLD-1 cells were inoculated into nude mice (n = 5 per group) at 3 × 10⁶ per mouse subcutaneously. Mice (n = 5) received 4 ng/kg TRAIL and 10 mg/kg cannabidiol either alone or in combination at day 30 after tumor implantation. Representative tumors of each group are shown. (C) TUNEL staining of paraffin-embedded tumors. (D) IHC staining for CHOP and DR5 in paraffin-embedded tumors. Scale bar 50 µm. (E) Proposed mechanism of cannabidiol activity. CBD, cannabidiol. ** p < 0.01.