Table 1.
Summary of PDX clinical trials.
| Author | Year1 | Origin2 | Cases3 | Strain4 | Site5 | Animals6 |
|---|---|---|---|---|---|---|
| Hammer [18] | 2010 | NSCLC7 | 22 | Nude | sc12 | 6 |
| Bertotti [20] | 2011 | CRC8 | 85 | NOD-scid | sc12 | 6 |
| Laheru [22] | 2012 | Pancreas | 14 | Nude | sc12 | 5 |
| Amendt [25] | 2014 | NSCLC7 | 45 | Nude | sc12 | 10 |
| Chen [41] | 2015 | CRC8 | 27 | Nude | sc12 | 5 |
| Gao [10] | 2015 | Solid tumor | 1075 | Nude | sc12 | 1 |
| Pan [50] | 2015 | Bladder | 22 | NSG | sc12/ortho13 | 8 to 10 |
| Guo [56] | 2016 | CRC8 | 25 | NSG | sc12 | Unknown |
| Gupta [57] | 2016 | GBM9 | 28 | Nude | ortho13 | 8 to 10 |
| Bialucha [67] | 2017 | Ovary/RCC10 | 30 | Nude | sc12 | 1 |
| Yao [87] | 2017 | CRC | 79 | Nude | sc12 | 1 |
| Einarsdottir [96] | 2018 | Melanoma | 31 | NOG | sc12 | 1 |
| Ruicci [107] | 2018 | HNSCC11 | 20 | NSG | sc12 | 2 |
| Zhong [113] | 2019 | Breast/Ovary | 23 | Nude | sc12 | 2 to 3 |
1 Publication year. 2 Origin of cancer for PDX models. 3 Number of PDX models. 4 Mouse strain. 5 Implantation site. 6 Number of animals per each treatment group. 7 Non-small cell lung cancer. 8 Colorectal cancer. 9 Glioblastoma. 10 Renal cell carcinoma. 11 Head and neck squamous cell carcinoma. 12 Subcutaneously implantation. 13 Orthotopic implantation.