Figure 1.

Effect of fucoxanthin (FX) and Phaeodactylum extract (PE) on lipid accumulation in 3T3-L1 cells during adipogenesis. Cells were cultured during differentiation (for six days) with FX, PE, or curcumin (CCM; reference). Accumulated lipids were stained with Oil-red O reagent and quantified by measuring the absorbance at 500 nm. (A) FX or CCM suppressed lipid accumulation; (B) PE and CCM inhibited lipid accumulation; (C) expression of proteins related to lipid accumulation (CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferator activated receptor γ (PPARγ), uncoupling protein-1 (UCP1)). The experiment was performed in triplicate. ***/**/* indicate significant differences at p < 0.001/ p < 0.01/p < 0.05 compared to the control (differentiation). N indicates no differentiation.