Table 4.
List of DAVID (Database for Annotation, Visualization and Integrated Discovery) functional annotation significantly enriched of differentially expressed genes (DEGs) in the cecal mucosa of broiler chickens.
| Categories and Functional Annotations 1 | % 2 | p-Value 1 | Benjamini Value 1 |
|---|---|---|---|
| KEGG_PATHWAY | |||
| Cysteine and methionine metabolism | 1.5 | 0.0001 | 0.012 |
| Cell cycle | 2.6 | 0.0001 | 0.009 |
| Focal adhesion | 3.3 | 0.0008 | 0.032 |
| UP_KEYWORDS | |||
| Disulfide bond | 11.3 | 0.0000 | 0.002 |
| Mitosis 3 | 2.0 | 0.0000 | 0.001 |
| Developmental protein | 4.8 | 0.0000 | 0.002 |
| Glycoprotein | 6.9 | 0.0000 | 0.002 |
| ATP-binding | 7.9 | 0.0002 | 0.008 |
| Secreted | 5.8 | 0.0002 | 0.007 |
| Alternative splicing | 3.0 | 0.0003 | 0.008 |
| Cytoskeleton | 2.8 | 0.0016 | 0.030 |
| Phosphoprotein | 4.3 | 0.0033 | 0.053 |
| GOTERM_BP_DIRECT | |||
| Chromosome segregation | 1.6 | 0.0000 | 0.044 |
| GOTERM_CC_DIRECT | |||
| Proteinaceous extracellular matrix 4 | 3.9 | 0.0000 | 0.000 |
| Midbody 5 | 2.0 | 0.0001 | 0.013 |
| Kinesin complex 6 | 1.5 | 0.0002 | 0.012 |
| GOTERM_MF_DIRECT | |||
| Heparin binding | 2.5 | 0.0000 | 0.001 |
| Chemoattractant activity | 1.2 | 0.0001 | 0.022 |
1 Protocol of DAVID functional analysis, as described by Reference [9]. 2 Percentages of the total differentially expressed genes (DEGs) obtained from DAVID analysis. 3,4,5,6 Other categories statistically significant: 3 cell division, centromere, cell cycle, nucleotide binding, DNA binding, chromosome; 4 extracellular exosome, extracellular space, focal adhesion; 5 spindle microtubule; 6 kinetocore, condensed chromosome kinetochore.