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. 2019 May 22;11(5):705. doi: 10.3390/cancers11050705

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LOXL1 promotes NSCLC invasion. (a) Invasion of H661 lung tumor cells was studied in an organotypic model in the presence of CAFs in which LOXL1 is overexpressed (CAF094-LOXL1) or knocked down (CAF094-shLOXL1). Acellular matrix (no CAF) and matrix populated with mock-CAF (CAF094-mock) were used as control. To visualize tumor cell invasion, H661 cells were stained using an epithelial cell adhesion molecule (Ep-CAM) antibody. Scale bar: 100 µm. Quantification of H661 invasion area (b) and invasion depth (c) in the matrix was performed using imageJ (n = 12 per condition, ***, p < 0.001; n.s., not significant; mean ± SD).