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SIRT2 downregulation impairs the expression and phosphorylation of tyrosine kinase receptor-associated pathways. The generated melanoma clones were treated with selected concentrations of dasatinib for 1 h. Then, protein lysates were prepared and analyzed by Western blotting. (b) Experiments performed using WM853 SCW3 and SSW30 clones. (a) Experiments performed using MDA-MB-435S SCM1 and SSM15 clones.
