Table 4.

Significant genes, proteins, and immune cell populations associated with the Nectin 4 score and significant correlations between clusters and these factors; and significant genes and pathways associated with NECTIN4 expression in HGSOC cell lines (n.a., not applicable).

Analytes Type	Tissue	N (Analytes)	FDR < 5% (<10%)	UP	Correlations FDR < 0%	Positive	Name of Table 1	Reference
RNA sequencing	Floating (ascites) and solid tumor cells	34,034 genes	908	643	n.a.		sign_RNAseq	[6,12]
--KEGG pathways		199	8 (9)	0 (0)	n.a.		sign_KEGG	-
--TCGA clusters		653	20 (58)	12 (42)	n.a.		sign_TCGA	-
--Gene-sets		17,810	1828	133	n.a.		sign_GS	-
Immune cells (FACS)	Ascites	43 cell populations	0	0	9	7	sign_A_FACS	[7]
	Blood	43 cell populations	0 (5)	(2)	44	10	sign_B_FACS	[7]
	Solid tumor tissue	43 cell populations	0	0	37	8	sign_T_FACS	[7]
Immune cells (IF)	Ascites	8 cell populations	0 (2)	0	8	4	sign_A_IF	[7]
Chemo/cytokines	Ascites	56	0	0	15	4	sign_A_Lum	[7]
	Serum	56	0	0	35	6	sign_S_Lum	[7]
Proteomics	Ascites	852	3 (4)	1 (2)	65	24	sign_A_Prot	-
RNA seq.	Cell lines	18,054 genes	57 (912) 2	53 (718) 2	n.a.		sign_RNAseq _CLs	[25]
KEGG pathways	Cell lines	199	4 (7) 2	4 (7) 2	n.a.		sign_KEGG _CLs	-

¹Supplementary Table S5—worksheets. ² FDR < 20%.