Table 2.
Technical aspects of 18F-PSMA PET/CT in the included studies.
| Authors | Radiotracer | Hybrid Imaging Modality | Fasting before Radiotracer Injection | Mean Radiotracer Injected Activity | Time Interval between Radiotracer Injection and Image Acquisition | Image Analysis | Other Imaging Performed for Comparison |
|---|---|---|---|---|---|---|---|
| Giesel et al. [29] | 18F-PSMA-1007 | PET/CT with low-dose CT | NR | 301 ± 46 (154–453) MBq | 92 ± 26 min | visual | - |
| Rousseau et al. [28] | 18F-DCFPyL | PET/CT with low-dose CT | yes (at least 4 h) | 369.2 ± 47.2 (237–474) MBq | 120 min | visual and semi-quantitative (SUVmax, SUVpeak, SUL, TLG, SUVratio) | - |
| Rahbar et al. [27] | 18F-PSMA-1007 | PET/CT with low-dose or contrast enhanced CT | NR | 338 ± 44.31 MBq (4 MBq/kg) | 120 min | visual and semi-quantitative (SUVmax) | - |
| Giesel et al. [26] | 18F-PSMA-1007 | PET/CT with low-dose CT | NR | 251.5 (154–326) MBq | 60 + 180 min | visual and semi-quantitative (SUVmax and SUVratio) | - |
| Rahbar et al. [25] | 18F-PSMA-1007 | PET/CT with low-dose or contrast enhanced CT | NR | 336.7 ± 46 MBq (4 MBq/kg) | 60 + 120 min | visual and semi-quantitative (SUVmax) | - |
| Mena et al. [24] | 18F-DCFBC | PET/CT with low-dose CT | NR | 292.3 (255.3–299.7) MBq | 60 + 120 min | visual and semi-quantitative (SUVmax) | mpMRI |
| Wondergem et al. [23] | 18F-DCFPyL | PET/CT with contrast enhanced CT | NR | 314 (243–369) MBq | 60 + 120 min | visual and semi-quantitative (SUVmax and SUVratio) | - |
| Dietlein et al. [22] | 18F-DCFPyL | PET/CT with low-dose CT | yes (at least 4 h) | 269.8 ± 81.8 MBq | 120 min | visual and semi-quantitative (SUVmax) | 68Ga-PSMA-11 PET/CT |
| Dietlein et al. [21] | 18F-DCFPyL | PET/CT with low-dose CT | yes (at least 4 h) | 318.4 ± 59.0 MBq | 120 min | visual and semi-quantitative (SUVmax and SUVratio) | 68Ga-PSMA-11 PET/CT |
Legend: MBq = MegaBecquerel; mpMRI = multi-parametric magnetic resonance imaging; NR = not reported; PET/CT = positron emission tomography/computed tomography; SUL = lean body mass standardized uptake value; SUVmax = maximal standardized uptake value; SUVpeak = peak standardized uptake value; SUVratio = lesion to background uptake ratio; TLG = total lesion glycolysis.