Effects of PPB isolated from ECE on vascular dysfunction and blood pressure in diet-induced mouse models of obese and hypertension (A,C) Light microscopic images showing proliferation marker (PCNA) and H&E stained blood vessels. (B,D) Plots showing numbers of PCNA positive cells and intima-media ratios obtained using representative H&E images (dark gray bar, Obese mouse model; gary bar, Hypertension mouse model). (E) Blood pressures, such as systolic, diastolic, and mean artery pressure in Obese and Hypertension mouse models. Scale bar = 10 μm (PCNA) and 200 μm (H&E). *, P < 0.05 vs. Sham group; $, P < 0.05 vs. Obese/Saline or Hypertension/Saline mice group. PCNA, Proliferating cell nuclear antigen; H&E, Hematoxylin and eosin. *, P < 0.05, **, P < 0.01 and ***, P < 0.001 vs. the sham group; $, P < 0.05, $$, P < 0.01 and $$$, P < 0.001 vs. Obese/Saline or Hypertension/Saline group. PPB, pyrogallol-phloroglucinol-6,6-bieckol.