Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 8;17(5):273. doi: 10.3390/md17050273

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Promising Red Sea brine specialized metabolite candidates. Five core structures for specialized metabolites were predicted using antiSMASH 4.0 [45]: (A) KD brine–seawater Lower Interface (KD LINF) site had two non-ribosomal peptides predicted to be synthesized by two non-ribosomal peptide synthetase (NRPS) clusters. (B) KD brine–seawater Upper Interface (KD UINF) site had a non-ribosomal peptide predicted to be synthesized by a NRPS cluster and a hybrid polyketide-non-ribosomal peptide predicted to be synthesized by T1PKS-NRPS. (C) ATII 1500 site had a polyketide predicted to be produced by a T1pks-pufa-otherks hybrid cluster. Four top promising candidate SMGCs were detected by ARTS [38]: (D) ATII brine Lower Convective Layer (ATII LCL) site had two clusters encoding Terpene and T3PKS. (E) ATII 200 site had a cluster encoding aryl polyene. (F) ATII 1500 site had a cluster encoding Otherks-PUFA-T1PKS (PUFA: polyunsaturated fatty acid). ser: serine, nrp: non-ribosomal peptide, gln: glutamine, gly: glycine, asp: aspartate, thr: threonine, pk: polyketide, ohmal: hydroxy malate.

Promising Red Sea brine specialized metabolite candidates. Five core structures for specialized metabolites were predicted using antiSMASH 4.0 [45]: (A) KD brine–seawater Lower Interface (KD LINF) site had two non-ribosomal peptides predicted to be synthesized by two non-ribosomal peptide synthetase (NRPS) clusters. (B) KD brine–seawater Upper Interface (KD UINF) site had a non-ribosomal peptide predicted to be synthesized by a NRPS cluster and a hybrid polyketide-non-ribosomal peptide predicted to be synthesized by T1PKS-NRPS. (C) ATII 1500 site had a polyketide predicted to be produced by a T1pks-pufa-otherks hybrid cluster. Four top promising candidate SMGCs were detected by ARTS [38]: (D) ATII brine Lower Convective Layer (ATII LCL) site had two clusters encoding Terpene and T3PKS. (E) ATII 200 site had a cluster encoding aryl polyene. (F) ATII 1500 site had a cluster encoding Otherks-PUFA-T1PKS (PUFA: polyunsaturated fatty acid). ser: serine, nrp: non-ribosomal peptide, gln: glutamine, gly: glycine, asp: aspartate, thr: threonine, pk: polyketide, ohmal: hydroxy malate.