Table 2.
Multinomial logistic analysis for univariate genetic associations.
| * Comparison 1 (Age Class 2 vs. Age Class 1) |
Comparison 2 (Age Class 3 vs. Age Class 1) |
Comparison 3 (Age Class 3 vs. Age Class 2) |
|||||
|---|---|---|---|---|---|---|---|
| 65–89 Years vs. <65 Years | 90+ vs. <65 Years | 90+ vs. 65–89 Years | |||||
| Gene | OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
| rs3745274-G/T | CYP2B6 | 0.97 (0.67–1.40) | 0.88 | 0.54 (0.37–0.80) | 0.002 | 0.56 (0.39–0.80) | 0.005 |
| rs776746-G/A | CYP3A5 | 1.20 (0.65–2.22) | 0.57 | 1.97 (1.08–3.56) | 0.022 | 1.66 (0.99–2.79) | 0.054 |
| rs4680-G/A | COMT | 1.67 (1.10–2.54) | 0.016 | 2.43 (1.58–3.73) | <0.001 | 1.47 (1.10–2.15) | 0.046 |
| rs2273697-G/A | ABCC2 | 0.87 (0.61–1.23) | 0.44 | 1.26 (0.89–1.79) | 0.18 | 1.45 (1.03–2.05) | 0.030 |
* In each comparison, the youngest group was considered as the reference category. For both comparisons 1 and 2 (both using the youngest group as reference category), odd ratios (ORs) were obtained directly from the equations included in the models; for comparison 3 (90+ years vs. <65 years), ORs were obtained by difference of equations included in the models.