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Partial least-squares discriminant analysis (PLS-DA) plots. (A) ESI+ and − modes of control vs. vitamin E nicotinate (TN); (B) ESI+ and − modes of control vs. vitamin E acetate + niacin (TA + N); (C) ESI+ and − modes of TN vs. TA + N. Human pulmonary artery smooth muscle cells were treated with either TN (100 µM) or with TA (100 µM) plus niacin (100 µM) (TA + N) for 10 min. Samples were subjected to metabolomics analysis (n = 9). ESI: electrospray ionization.
