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. 2019 May 10;11(5):648. doi: 10.3390/cancers11050648

Figure 6.

Figure 6

Cytokines, gastrin G17 and pepsinogen PGI association with TLR9 polymorphism. (A) IL-8 and (B) IL-18 cytokines titer were tested using a Luminex MagPlex based assay and result stratified based on the carriers TLR9 rs5743836 polymorphism. A significant increase in the mean IL-8 titer was found associated with the presence of the TLR9 T/T genotype (A). Samples tested were n = 70 GC, samples duplicated with a CV > 15% were excluded from the analysis and they are not reported in the figure. The mean of IL-18 levels between the 2 TLR9 genotypes (C/T and C/C vs. T/T) did not reach a statistical difference (B). TLR9 T/T genotype was found associated to highest mean level of gastrin G17 in the AAG group (C) but not in GC (E). TLR9 T/T genotype was found associated with a mean slightly higher PGI level in AAG (D) and in GC (F), although in both the groups the difference did not reach a significant difference. Compared to AAG, the mean of PG1 level is higher in GC.