Table 4. . Revised CYP2D6 allele frequencies.
| CYP2D6 allele | African–American (n = 160) | Asian (n = 174) | Caucasian (n = 166) | Hispanic (n = 162) | Ashkenazi Jewish (n = 192) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Freq. | 95% CI | Freq. | 95% CI | Freq. | 95% CI | Freq. | 95% CI | Freq. | 95% CI | |
| Increased function | ||||||||||
| *1×2 | 0.013 | 0.000–0.030 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.006 | 0.000–0.018 | 0.026 | 0.004–0.049 |
| *2×2 | 0.025 | 0.001–0.049 | 0.011 | 0.000–0.027 | 0.012 | 0.000–0.029 | 0.018 | 0.000–0.039 | 0.078 | 0.040–0.116 |
| Subtotal | 0.038 | 0.011 | 0.012 | 0.024 | 0.104 | |||||
| Normal function | ||||||||||
| *1 | 0.256 | 0.189–0.324 | 0.273 | 0.207–0.339 | 0.361 | 0.288–0.435 | 0.475 | 0.398–0.552 | 0.313 | 0.247–0.378 |
| *2 | 0.213 | 0.149–0.276 | 0.142 | 0.090–0.194 | 0.169 | 0.112–0.226 | 0.226 | 0.162–0.290 | 0.099 | 0.057–0.141 |
| *29×2 | 0.006 | 0.000–0.018 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *35 | 0.000 | 0.000–0.000 | 0.011 | 0.000–0.027 | 0.066 | 0.028–0.104 | 0.024 | 0.001–0.048 | 0.026 | 0.004–0.049 |
| Subtotal | 0.475 | 0.426 | 0.596 | 0.725 | 0.438 | |||||
| Decreased function | ||||||||||
| *9 | 0.000 | 0.000–0.000 | 0.006 | 0.000–0.017 | 0.012 | 0.000–0.029 | 0.024 | 0.001–0.048 | 0.005 | 0.000–0.015 |
| *10 | 0.044 | 0.012–0.075 | 0.136 | 0.086–0.187 | 0.030 | 0.004–0.056 | 0.000 | 0.000–0.000 | 0.078 | 0.040–0.116 |
| *17 | 0.125 | 0.074–0.176 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.006 | 0.000–0.018 | 0.010 | 0.000–0.025 |
| *29 | 0.106 | 0.059–0.154 | 0.006 | 0.000–0.017 | 0.000 | 0.000–0.000 | 0.006 | 0.000–0.018 | 0.000 | 0.000–0.000 |
| *36+*10 | 0.000 | 0.000–0.000 | 0.153 | 0.100–0.207 | 0.006 | 0.000–0.018 | 0.006 | 0.000–0.018 | 0.005 | 0.000–0.015 |
| *36×2+*10 | 0.000 | 0.000–0.000 | 0.057 | 0.023–0.092 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *41 | 0.025 | 0.001–0.049 | 0.074 | 0.035–0.113 | 0.127 | 0.076–0.177 | 0.073 | 0.033–0.113 | 0.141 | 0.091–0.190 |
| *41×2 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| Subtotal | 0.300 | 0.432 | 0.175 | 0.116 | 0.240 | |||||
| No function | ||||||||||
| *3 | 0.000 | 0.000–0.000 | 0.006 | 0.000–0.017 | 0.018 | 0.000–0.038 | 0.006 | 0.000–0.018 | 0.005 | 0.000–0.015 |
| *4 | 0.069 | 0.030–0.108 | 0.051 | 0.019–0.084 | 0.169 | 0.112–0.226 | 0.091 | 0.047–0.136 | 0.203 | 0.146–0.260 |
| *4×2 | 0.050 | 0.016–0.084 | 0.000 | 0.000–0.000 | 0.006 | 0.000–0.018 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *5 | 0.056 | 0.021–0.092 | 0.046 | 0.015–0.077 | 0.018 | 0.000–0.038 | 0.030 | 0.004–0.057 | 0.005 | 0.000–0.015 |
| *6 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.006 | 0.000–0.018 | 0.000 | 0.000–0.000 | 0.005 | 0.000–0.015 |
| *7 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *8 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *11 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *14 | 0.000 | 0.000–0.000 | 0.011 | 0.000–0.027 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *15 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| *36 | 0.013 | 0.000–0.030 | 0.006 | 0.000–0.017 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 | 0.000 | 0.000–0.000 |
| Subtotal | 0.188 | 0.120 | 0.217 | 0.128 | 0.219 | |||||
Freq.: Frequency.