Figure 10.

Comparative time course analysis of motoneuron-like cell survival (A), astrogliosis (B), Iba-1⁺ cell reaction (C) and synaptic covering (D) in WT and β2m KO mice. Note that the progressive loss of motoneuron-like cells is equivalent in both strains, despite astrogliosis in β2m KO that did not show increasing over time. On the other hand, the Iba-1⁺ cells reaction was more intense in β2m KO mice in the acute phase after VRC, which was coincident to a more pronounced synaptic detachment in the same strain, a difference that was detected also 28 dpi. Graphs show the comparative quantification among time points (ipsi/contralateral ratios); Significance levels: * p < 0.5, ** p < 0.01, *** p < 0.001.