Figure 6.

ADAADi injection into PC3‐induced mouse xenografts reduces, and in some cases, inhibits tumor growth. Three independent xenograft experiments were initiated by injection of PC3 cells. Tumor size was plotted as a function of time following injection of ADAADi or the control solution directly into the tumors. The number of xenografts (n) in each cohort is indicated. Data points for each individual mouse are indicated by specific shapes and colors. In Experiment 1 (a,b) and Experiment 2 (c,d), tumors were injected with PBS or ADAADi every other day for two weeks. In Experiment 3 (e,f), tumors were injected with ADAADi or with kanamycin instead of PBS as a control every other day for two weeks and after a one week break from treatment, an additional set of injections were performed every other day for two weeks. ADAADi: active DNA‐dependent ATPase A Domain inhibitor [Color figure can be viewed at wileyonlinelibrary.com]