Table 1.
Genome-wide association and Immunochip studies on inflammatory bowel disease susceptibility genes in Asia [46].
| Disease | Country | Study | New SNP | Positional Candidate Gene or Region | Replicated Gene or Region | Reference |
|---|---|---|---|---|---|---|
| CD | Japan | GWAS | rs1487630 | 4p14 | MHC | [41] |
| rs7329174 | ELF1 | TNFSF15 | ||||
| STAT3 | ||||||
| Korea | GWAS | rs6856616 | TBC1D1-KLF3 | TNFSF15 | [42] | |
| rs11195128 | SMNDC1-DUSP5 | IL23R | ||||
| rs11235604 | ATG16L2 | MHC | ||||
| rs11235667 | ATG16L2-FCHSD2 | RNASET2-FGFR10P-CCR6 | ||||
| Korea | Immunochip | GPR35 | [43] | |||
| ZNF365 | ||||||
| ZMIZI | ||||||
| NKX2-3 | ||||||
| PTPN2 | ||||||
| USP25 | ||||||
| Japan | GWAS | rs488200 | RAP1A | TNFSF15 | [44] | |
| HLA-DQB1 | ||||||
| 4p14 | ||||||
| ZNF365 | ||||||
| IL12B | ||||||
| IL27 | ||||||
| IL23R G149R | ||||||
| UC | Japan | GWAS | rs1801274 | FCGR2A | JAK2, INSL6, INSL4 | [47] |
| rs17085007 | 13q12 | MHC | ||||
| rs2108225 | SLC26A3 | |||||
| Korea | GWAS | MHC | [48] | |||
| 16q24.1 | ||||||
| RNF186-OTUD3-PLA2G2E | ||||||
| Korea | Immunochip | IL23R | [49] | |||
| IRF5 | ||||||
| (JAK2) | ||||||
| (TNFRSF14) | ||||||
| (IL10-1L19) | ||||||
| TNFSF15 | ||||||
| (UBE2L3-YDJC) | ||||||
| FCGR2A | ||||||
| (GPR12-USP12) | ||||||
| India | GWAS | rs2261033 | BAT2 | PTPRC | [50] | |
| rs2736428 | SLC44A4 | MHC | ||||
| rs2075800 | HSPA1L | TAP2 | ||||
| rs549182 | NOTCH4 | |||||
| rs4151657 | CFB | |||||
| rs3749946 | 3.8-1/HCG26 | |||||
| rs707939 | MSH5 |
CD = Crohn’s disease, UC = ulcerative colitis, GWAS = genome-wide association study, MHC = major histocompatibility complex, () = denotes nearby genes.