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. 2019 Apr 8;14(9):982–993. doi: 10.1002/cmdc.201900023

Scheme 4.

Scheme 4

Separation of enantiomers using derivatisation method with chiral alcohols: a) EDCI, DMAP, CH2Cl2, 23 °C, 16 h, 54 %; b) EDCI, DMAP, CH2Cl2, 23 °C, 4 h, 31 %; c) DBU, toluene, 80 °C, 4 h; d) EDCI, DMAP, CH2Cl2, 23 °C, 16 h, 54 %; e) CuCl, MeOH, 40 °C, 6 h.