Table 2.
Alterations in MCM genes in human cancers.
| Cancer Type | No. of Cases | MCM2 | MCM3 | MCM4 | MCM6 | MCM7 | MCM8 | MCM9 | MCM10 |
|---|---|---|---|---|---|---|---|---|---|
| Stomach adenocarcinoma | 1131 | 3.45% (M) |
- | 3.71% (M) |
- | 5.13% (A) |
4.42% (M) |
- | - |
| Serous ovarian cancer | 1191 | 3.78% (A) |
- | 3.61% (A) |
- | 4.11% (A) |
5.04% (A) |
- | 4.79% (A) |
| Head and neck squamous cell carcinoma | 1332 | 3.38% (A) |
- | 5.11% (A) |
- | 5.03% (A) |
- | - | - |
| Cutaneous melanoma | 892 | 3.03% (M) |
- | - | - | - | 3.03% (M) |
- | 3.14% (M) |
| Uterine endometrioid carcinoma | 1242 | 3.22% (M) |
- | 3.7% (M) |
- | - | - | - | - |
| Esophageal adenocarcinoma | 255 | - | 6.67% (A) |
- | - | 12.55% (A) |
3.92% (A) |
3.53% (M) 3.92% (A) |
- |
| Hepatocellular carcinoma | 798 | - | - | 5.26% (A) |
- | - | - | - | - |
| Invasive breast carcinoma | 954 | - | - | 4.61% (A) |
- | - | - | - | - |
| Pancreatic adenocarcinoma | 360 | - | - | 3.33% (A) |
- | 3.33% (A) |
- | - | - |
| Prostate adenocarcinoma | 1803 | - | - | 3.61% (D) |
- | - | 6.16% (D) |
- |
Note: Data were obtained from www.cbioportal.org in April 2019. Alterations with a frequency >3% and patient cohort size >250 were included. A, amplification; D, deletion; M, mutation.