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. 2019 Apr 19;34(5):697–707. doi: 10.1002/mds.27695

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© 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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LID prevention study. (A) Treatment timeline. (B) Peak dose LID severity (80 minutes postlevodopa) across time and doses. (C) Daily time course (20‐170/200 minutes postlevodopa). For each dose and day, the top graphs reflect mean ± SEM; bottom graphs show individual subject responses over time. Statistics: Friedman and Kruskal‐Wallis tests with Dunn's multiple‐comparison post hoc as shown in graphs. Scr, rAAV‐Scrambled‐shRNA (n = 7); CaV, rAAV‐CaV1.3‐shRNA (n = 10). [Color figure can be viewed at wileyonlinelibrary.com]