Table 2.
Serum biochemical data from mice fed treatment diets for 21 d.
| Item | Control 1 | Chanoclavine 1 | SED | p-Value |
|---|---|---|---|---|
| Males | ||||
| CK (IU/L) | 294 ± 69 | 437 ± 206 | 91.6 | 0.164 |
| AST (IU/L) | 75 ± 15 | 75 ± 20 | 11.1 | 0.972 |
| ALT (IU/L) | 37 ± 12 | 35 ± 6 | 6.0 | 0.748 |
| T.Bil (µmol/L)2 | 1.8 ± 0.4 a | 0.9 ± 0.2 b | 0.2 | 0.004 |
| TP (g/L) | 54.0 ± 2.2 | 53.8 ± 2.0 | 1.4 | 0.886 |
| ALB (g/L) | 33.2 ± 0.8 | 33.0 ± 1.4 | 0.7 | 0.786 |
| Globulin (g/L) | 20.8 ± 2.9 | 20.0 ± 1.4 | 1.5 | 0.616 |
| A/G | 1.622 ± 0.230 | 1.660 ± 0.178 | 0.1 | 0.787 |
| CRN (µmol/L) | 14.0 ± 2.8 | 17.0 ± 5.8 | 2.9 | 0.328 |
| Na (mmol/L) | 146 ± 2 | 146 ± 1 | 0.9 | 0.829 |
| K (mmol/L) | 15.0 ± 1.4 | 15.3 ± 1.3 | 0.9 | 0.700 |
| Cl (mmol/L) | 103 ± 1 | 105 ± 1 | 0.6 | 0.101 |
| Females | ||||
| CK (IU/L) | 569 ± 210 | 594 ± 209 | 132.6 | 0.851 |
| AST (IU/L) | 110 ± 20 | 121 ± 17 | 11.7 | 0.366 |
| ALT (IU/L) | 31 ± 5 | 39 ± 9 | 4.5 | 0.126 |
| T.Bil (µmol/L) 2 | 1.5 ± 0.7 | 0.9 ± 0.2 | 0.3 | 0.108 |
| TP (g/L) | 54.8 ± 1.1 b | 57.8 ± 2.3 a | 1.1 | 0.029 |
| ALB (g/L) | 36.6 ± 1.1 b | 38.8 ± 1.5 a | 0.8 | 0.030 |
| Globulin (g/L) | 18.2 ± 0.8 | 19.0 ± 1.6 | 0.8 | 0.347 |
| A/G | 2.015 ± 0.140 | 2.053 ± 0.181 | 0.1 | 0.721 |
| CRN (µmol/L) | 17.0 ± 0.7 | 16.8 ± 3.7 | 1.7 | 0.908 |
| Na (mmol/L) | 148 ± 1 | 148 ± 4 | 1.8 | 0.913 |
| K (mmol/L) | 12.4 ± 1.0 | 12.8 ± 2.1 | 1.0 | 0.682 |
| Cl (mmol/L) | 106 ± 1 | 106 ± 2 | 0.9 | 0.838 |
1 Values are means ± standard deviation (n = 5). Fisher’s least significant difference was used to compare treatment means. Two means that have no letter in common are statistically different at the 5% level. If no letters are given, the overall p-value was not statistically significant at the 5% level. 2 When total bilirubin (T. Bil) was below the detection limit it was assigned a value of half the detection limit (0.5 µmol/L). CK, creatine kinase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TP, total protein; ALB, albumin; CRN, creatinine.