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. 2019 Jan 10;20(2):105–111. doi: 10.2217/pgs-2018-0140

Figure 1. . Schematic of the intracellular phosphorylation of TFV.

Figure 1. 

TFV requires two sequential phosphorylation steps to become a pharmacologically active triphosphate analogue, denoted as TFV-DP. Lade et al. [19] discovered that AK2 can catalyze the phosphorylation of TFV to TFV-MP in peripheral blood mononuclear cells, vaginal, and colorectal tissues. In addition, PKM and PKLR were found to catalyze the phosphorylation of TFV-MP to TFV-DP in peripheral blood mononuclear cells and vaginal tissue, while CKM phosphorylated TFV-MP to TFV-DP in colorectal tissue.

AK2: Adenylate kinase 2; CKM: Creatine kinase muscle; DP: Diphosphate; MP: Monophosphate; PKM: Pyruvate kinase muscle; PKLR: Pyruvate kinase liver and red blood cell; TFV: Tenofovir.