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. 2019 Jun 6;10:1297. doi: 10.3389/fimmu.2019.01297

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Copyright © 2019 Lejeune, Brachet and Watier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Genomic organization of the FCGR2/3 cluster in mammals. Bioinformatic analysis of orthologous genes of human FCGR2A, FCGR2B, and FCGR3A (blue, yellow, and purple backgrounds, respectively). For gorilla and chimpanzee, the FCGR2/3 cluster is characterized by additional human orthologous FCGR2C and FCGR3B genes. Similarly, orthologous genes of human HSPA6 (red background) were found in all studied species whereas only gorilla and chimpanzee possess human orthologous HSPA7. (B) Non allelic homologous recombination between FCGR2A and FCGR2B leading to duplication of FCGR4 (giving birth to FCGR3B and FCGR3A) and emergence of FCGR2C.