Table 2.
The relative expression of genes associated with oxidative stress. The results are expressed as a mean. p < 0.05 was considered statistically significant, *** p < 0.001, ** p < 0.001 as compared to the control. RelA—transcription factor p65, FOXO3—forkhead box O3, HIF1α—hypoxia inducible factor 1α, DON—deoxynivalenol, Cnt—control.
| Androgen Dependency | Cell Line | Dose | RelA | FOXO3 | HIF1α |
|---|---|---|---|---|---|
| Androgen-dependent cell lines | 22Rv1 | 5 µM DON | 4.940 *** | 1.760 *** | 1.152 *** |
| 3 µM DON | 5.045 *** | 1.300 *** | 1.021 *** | ||
| 2 µM DON | 5.015 *** | 0.9127 *** | 0.8682 *** | ||
| Cnt | 0.8955 | 0.4464 | 0.2178 | ||
| LNCaP | 5 µM DON | 9.409 *** | 1.557 *** | 1.557 *** | |
| 3 µM DON | 7.976 *** | 1.075 *** | 1.073 *** | ||
| 2 µM DON | 7.424 *** | 1.010 *** | 1.012 *** | ||
| Cnt | 0.7651 | 0.2067 | 0.2066 | ||
| Androgen-independent cell lines | PC3 | 5 µM DON | 9.593 *** | 5.230 *** | 5.228 *** |
| 3 µM DON | 8.874 *** | 5.765 *** | 5.765 *** | ||
| 2 µM DON | 7.222 *** | 4.850 *** | 4.848 *** | ||
| Cnt | 3.803 | 3.245 | 3.246 | ||
| DU-145 | 5 µM DON | 6.836 *** | 1.499 *** | 1.784 *** | |
| 3 µM DON | 5.495 *** | 1.163 *** | 1.867 *** | ||
| 2 µM DON | 6.307 *** | 1.125 *** | 2.214 *** | ||
| Cnt | 2.17 | 0.4242 | 1.275 |