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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Lancet Haematol. 2018 Dec 10;6(1):e29–e37. doi: 10.1016/S2352-3026(18)30182-0

Figure 3. TP53 mutations in 24 patients.

Figure 3.

(A) Schematic of TP53 protein showing mutational spectrum in 24 patients. Two patients had H193L and V272M TP53 mutations. TAD - transactivation domain (1–42); PRD - proline-rich domain (40–92); DBD - DNA-binding domain (101–306); OD - oligomerization domain (307–355); CTD - C-terminal regulatory domain (356–393). (Adapted with permission from http://p53.free.fr). (B) Change in variant allele frequencies of TP53 by response versus no response to decitabine in 13 patients with paired samples.