Table 2.
Diagnoses (primary or secondary), surgical procedures, and pharmacotherapy used for defining the study population, comorbidity, concomitant treatment, and outcomes
| Details | ICD-8, ICD-10, and ATC codes used | |
|---|---|---|
| Study population | ||
| Heart failure | Defined from diagnosis codes including heart failure, cardiomyopathies, hypertensive heart failure |
ICD-10: I110, I130, I132, I42, I426-29, I50 ICD-8: 425, 428 |
| Diabetes | Defined from treatment with glucose-lowering drugs | ATC: A10 |
| Comorbidity | ||
| Diabetes |
ICD-10: E10-E14 ICD-8: 250 |
|
| Stroke |
ICD-10: I60-I64 ICD-8: 430-434, 436 |
|
| Ischemic heart disease |
ICD-10: I21-25 ICD-8: 410-414 |
|
| Chronic kidney disease | Defined from diagnosis codes of chronic glomerulonephritis, chronic tubulointerstitial nephropathy, chronic kidney disease, and diabetic and hypertensive nephropathy. |
ICD-10: N02-N04, N18-N19, I12, I13 ICD-8: 582-6, 588 |
| Atrial fibrillation |
ICD-10: I48 42,793, 42,793 |
|
| Cancer | Defined from all cancer diagnosis codes, excluding non-melanoma skin cancer |
ICD-10: C00-C97 ICD-8: 140-209 |
| Chronic obstructive pulmonary disease |
ICD-10: J42, J44 ICD-8: 490–492 |
|
| Hypertension |
ICD 10: I10-I15 ICD-8: 400-404 |
|
| Concomitant pharmacotherapy | ||
| Statins | ATC: C10A | |
| Beta-blockers | ATC: C07 | |
| Aldosterone antagonists | ATC: CO3D | |
| Platelet inhibitors | ATC: B01AC04, BO1AC06 | |
| Digoxin | ATC: C01AA05 | |
| Thiazides | ATC CO3A | |
| Renin angiotensin system inhibitors | Including angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers | ATC: C09 |
| Loop diuretics | ATC: C03CA01 | |
| Insulin | ATC: A10A | |
| Metformin | ATC A10BA02 | |
| Sulfonylurea | ATC: A10BB | |
| Thiazolide | ATC: A10BG | |
| Dipeptidyl peptidase-4 inhibitor | ATC: A10BB | |
| Glucagon-like peptide-1 | ATC: A10BG | |
| Sodium-glucose co-transporter-2 | ATC: A10BK | |
| Combination of two anti-diabetic drugs | Either a combination of metformin, sulfonylurea, thiazolidinedione, dipeptidyl peptidase-4 inhibitor, sodium-glucose cotransporter-2 or glucagon-like peptide-1 receptor agonist | ATC: A10BD |
Diagnoses (primary or secondary), surgical procedures, and pharmacotherapy used for defining the study population, comorbidity, concomitant treatment, and outcomes
ATC: Anatomical Therapeutic Chemical (ATC) system; ICD-8: 8th revision of the International Classification of Diseases system; ICD-10: 10th revision of the International Classification of Diseases system